p11: evening primrose oil improves nerve functions following crush injury of sciatic nerve in rats

Authors

omid badri department of physiology, school of medicine, tabriz university of medical sceinces, tabriz, iran.

parviz shahabi neuroscience research center, tabriz university of medical sciences, tabriz, iran.

mehdi farhoudi neuroscience research center, tabriz university of medical sciences, tabriz, iran.

mohsen sharif-zak department of biochemistry, school of medicine, tabriz university of medical sceinces, tabriz, iran.

abstract

repairing the damaged nerves caused by physical injury (trauma), is one of the major challenges facing modern medical sciences. evening primrose oil (epo) extraction of oenothera biennis seed that enriches with omega-6,γ-linoleic acid and linoleic acid that they have essential role in myelination and neural membrane structure. the aim of this study was to evaluate the functional recovery of sciatic nerve after epo administration in crushed sciatic nerves. eighteen male wistar rats with 180 - 200g weight divided in 3 groups: sham, saline, epo. in 12 anesthetized rats in saline, epo groups, the right sciatic nerve was crushed using a small hemostatic forceps. epo, 450 mg/kg/day, was orally administrated for 28 days. gastrocnemius muscle atrophy was investigated using light microscopy. functional recovery of the nerves was assessed using sciatic functional index sfi one day before injury and 7, 14, 21 and 28days after injury. the result of this study showed that in epo group, functional recovery of sciatic nerve significantly accelerated compared with group 2 that received saline. in addition the muscular atrophy improvement was greater in epo group compared with saline group. the present study showed that epo induced improving effect on motor function and muscular atrophy caused by nerve crush injury.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

The Changes in Rats with Sciatic Nerve Crush Injury Supplemented with Evening Primrose Oil: Behavioural, Morphologic, and Morphometric Analysis

Nerve crush injuries are commonly used models for axonotmesis to examine peripheral nerve regeneration. As evening primrose oil (EPO) is rich in omega-6 essential fatty acid component and gamma-linolenic acid, studies have shown the potential role of EPO in myelination. Seventy-two healthy adult Sprague-Dawley rats were classified into three groups: normal group, control group, and experimental...

full text

Sciatic functional index following induction of injury in the sciatic nerve of rats

Sciatic functional index (SFI) as a behavioral method was used to assess the functional recovery following experimentally-induced various injuries in the sciatic nerve, spinal cord, and brain. In the present study, the functional recovery after induction of injury in the sciatic nerve was investigated in rats using SFI. Twenty-four rats were divided into three groups including sham-operated (SS...

full text

Sciatic functional index following induction of injury in the sciatic nerve of rats

Sciatic functional index (SFI) as a behavioral method was used to assess the functional recovery following experimentally-induced various injuries in the sciatic nerve, spinal cord, and brain. In the present study, the functional recovery after induction of injury in the sciatic nerve was investigated in rats using SFI. Twenty-four rats were divided into three groups including sham-operated (SS...

full text

Crocin Enhanced Functional Recovery after Sciatic Nerve Crush Injury in Rats

Objective(s): Crocin is a constituent of saffron and has many biological functions. The present study aimed to investigate the effects of intraperitoneal (IP) injection of crocin on sciatic nerve regeneration in male Wistar rats. Materials and Methods: Fifty-four rats were divided into 9 groups: groups 1-4 (intact + normal saline and intact + crocin at doses of 5, 20 and 80 mg/kg, respectively)...

full text

Lysosomes in the Rat Sciatic Nerve following Crush

Peripheral nerves undergoing degeneration are favorable material for studying the types, origins, and functions of lysosomes. The following lysosomes are described: (a) Autophagic vacuoles in altered Schwann cells. Within these vacuoles the myelin and much of the axoplasm which it encloses in the normal nerve are degraded (Wallerian degeneration). The delimiting membranes of the vacuoles appare...

full text

My Resources

Save resource for easier access later


Journal title:
مجله علوم اعصاب شفای خاتم

جلد ۲، شماره ۴، صفحات ۶۱-۶۱

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023